Are you or your loved one

and experiencing voice changes and the slowing of movements?

It may be Progressive Supranuclear Palsy, or PSP, and you or your loved one may be eligible to participate in the Arise Study.

Are you or your loved one falling and experiencing voice changes and the slowing of movements?

We invite those 40 years of age or older who are experiencing symptoms of PSP to see if they may qualify for the Arise Study. The purpose of this research study is to test the efficacy and long-term safety and tolerability of an investigational study medication in patients with PSP.

Each person will be evaluated to determine if participation in the Arise Study is right for them. Those who are able to participate will receive the investigational study medication or a placebo (inactive drug) and study-related medical care at no cost. Taking part in this research study is voluntary, and you or your loved one can stop participating at any time. Please note that a dedicated caregiver must be able to attend visits with the study participant. Reimbursement for travel may also be available.

See If You May Qualify

Purpose of the Arise Study.

The purpose of this research study is to test the efficacy and long-term safety and tolerability of an investigational study medication (ABBV-8E12) in patients with PSP.
The Arise Study - Progressive Supranuclear Palsy, or PSP

Who may qualify.

The Arise Study may be appropriate for those who meet the following criteria:

  • 40 years of age or older
  • Diagnosed with PSP (however, a formal diagnosis is not required)
  • Showing symptoms of PSP, including problems moving one’s eyes up and down or unsteadiness or falls for less than five years
  • Able to undergo magnetic resonance imaging (MRI), which is a scan to produce an image of the brain
  • Able to undergo a lumbar puncture, which is a procedure to collect spinal fluid from the lower back (in certain medically approved circumstances this will not be required)
  • Able to walk at least five steps with little assistance (e.g., use of cane/walker)
  • Able to identify someone who can act as a study partner, such as a caregiver, who spends at least 10 hours a week with the patient and can accompany the patient to study visits
See If You May Qualify

Study details.

After you or your loved one gives consent to participate in this research study, you or your loved one will have an initial screening visit. This visit will include blood work, neurological testing, administration of diagnostic scales/questionnaires, and a brain MRI to determine if you or your loved one is able to participate. Also at this visit, a lumbar puncture may be performed. If this study is a good fit, you or your loved one will receive either the investigational study medication or a placebo (inactive drug).

After joining the study, you or your loved one will receive the investigational study medication or a placebo by IV infusion approximately every four weeks for 48 weeks. There will also be periodic follow-up visits with the study doctor to undergo blood work, clinical and neurological examinations, diagnostic scales/questionnaires, and a review of how study participants are feeling. Throughout the study, participants will have brain MRIs (between four and five) and lumbar punctures (between zero and three). These tests will take several hours but will not require an overnight stay in the hospital. However, accommodations may be provided if you prefer to stay overnight due to long visit days.