After you or your loved one gives consent to participate in this research study, you or your loved one will have an initial screening visit. This visit will include blood work, neurological testing, administration of diagnostic scales/questionnaires, and a brain MRI to determine if you or your loved one is able to participate. Also at this visit, a lumbar puncture may be performed. If this study is a good fit, you or your loved one will receive either the investigational study medication or a placebo (inactive drug).
After joining the study, you or your loved one will receive the investigational study medication or a placebo by IV infusion approximately every four weeks for 48 weeks. There will also be periodic follow-up visits with the study doctor to undergo blood work, clinical and neurological examinations, diagnostic scales/questionnaires, and a review of how study participants are feeling. Throughout the study, participants will have brain MRIs (between four and five) and lumbar punctures (between zero and three). These tests will take several hours but will not require an overnight stay in the hospital. However, accommodations may be provided if you prefer to stay overnight due to long visit days.